Palladium-catalyzed asymmetric benzylation of 3-aryl oxindoles.
نویسندگان
چکیده
Herein we report palladium-catalyzed asymmetric benzylic alkylation with 3-aryl oxindoles as prochiral nucleophiles. Proceeding analogously to asymmetric allylic alkylation, asymmetric benzylation occurs in high yield and enantioselectivity for a variety of unprotected 3-aryl oxindoles and benzylic methyl carbonates using chiral bisphosphine ligands. This methodology represents a novel asymmetric carbon-carbon bond formation between a benzyl group and a prochiral nucleophile to generate a quaternary center.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 132 44 شماره
صفحات -
تاریخ انتشار 2010